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The acclaimed television series will spotlight how Samsung is redefining customer care through advanced training programs, cutting-edge solutions, and a people-first approach.

NEW YORK, NY / ACCESS Newswire / November 21, 2025 / Samsung Electronics America will be featured on an upcoming episode of “Trending Today” airing on Fox Business on November 23rd at 5:30 pm EST. The national feature highlights Samsung’s growing leadership in customer support and shines a light on the brand’s significant investment in technician training, innovation, and service excellence.

“Trending Today” showcases global innovation across a broad spectrum of industries–including technology, business and development, health and wellness, and luxury lifestyles. The series highlights the journeys of companies that are pushing boundaries and setting new standards for excellence.

Among the brands featured this season, Samsung stands out for its commitment to empowering customers through world-class support and highly skilled technicians. With millions of households relying on Samsung products, the company is investing heavily in hands-on training programs so technicians can diagnose issues faster, deliver more accurate solutions, and elevate the overall service experience. From smart appliances and home entertainment systems to mobile devices and wearables, Samsung’s Customer Care Team is trained to resolve complex challenges with expertise and empathy.

“At ‘Trending Today,’ we spotlight companies that are transforming the way people live and work,” said Liz Plummer, executive producer of “Trending Today.” “Samsung impressed us with its deep commitment to service–particularly its investment in technician education and real-world training. Their dedication to empowering both customers and employees perfectly reflects the innovative spirit we strive to showcase.”

Episode viewers will explore Samsung’s state-of-the-art training programs, which equip technicians with the latest knowledge in diagnostics, repair, and customer communication. These initiatives are backed by major corporate investment to ensure consumers receive fast, reliable, and solution-oriented support–whether in-home, in-store, or online. Samsung’s approach emphasizes not only technical accuracy but also building trust and confidence with every customer interaction.

For more than 13 years, “Trending Today” has highlighted innovators and industry leaders across consumer products, luxury lifestyles, health, and technology. Recently recognized with multiple Telly Awards, the acclaimed series continues its tradition of spotlighting standout companies that are shaping the future.

To learn more about “Trending Today,” visit www.trendingtoday.com.

About Trending Today

Trending Today, the acclaimed television series airing on A&E, Bloomberg, and Fox Business, captures the entrepreneurial ambition that drives innovation around the world. Each episode highlights the latest technologies, market trends, and groundbreaking ideas through a thoughtfully selected lineup of inventors, innovators, and thought leaders. Covering a wide range of industries-including consumer products, luxury lifestyles, health, and technology-Trending Today features companies and people who are pushing boundaries and redefining excellence. To learn more, visit www.trendingtoday.com.

Media contact:

Liz Plummer 
Liz@trendingtoday.com

SOURCE: Trending Today

View the original press release on ACCESS Newswire

Episode airing Saturday, November 23 at 5:30 p.m. EST features Samsung Electronics America, Bradford Custom Homes and Remodeling, and LegalEASE

NEW YORK, NY / ACCESS Newswire / November 21, 2025 / Three powerhouse brands–each transforming its industry through innovation, education, and an unwavering commitment to excellence–will be featured in the new episode of “Trending Today,” airing Saturday, November 23 at 5:30 p.m. EST on Fox Business. This carefully curated episode spotlights leaders in customer service, luxury homebuilding and remodeling, and employee legal benefits: Samsung Electronics America, Bradford Custom Homes, and LegalEASE.

For more than 13 seasons, “Trending Today” has profiled the inventors, innovators, and industry visionaries who are defining what’s next across business services, technology, wellness, real estate, and luxury lifestyles. This new episode continues that mission by featuring companies whose work elevates the everyday experience at home, at work, and in life’s most pivotal moments.

“At ‘Trending Today,’ our goal is to highlight exceptional organizations that set new standards for quality, service, and innovation,” said Liz Plummer, Executive Producer of “Trending Today.” “Samsung, Bradford Custom Homes and Remodeling, and LegalEASE each reflect world-class leadership within their fields. We are thrilled to share their stories with a national audience on Fox Business.”

Samsung Electronics America

Samsung Electronics America opens the episode with an in-depth profile of its rapidly advancing Customer Care operations. With millions of households relying on Samsung products, the company is reshaping the service experience through significant corporate investment in technician education, hands-on diagnostic training, and customer-focused solutions.

From appliances and home entertainment to mobile devices and wearables, Samsung’s Customer Care Team is equipped with cutting-edge knowledge and real-world skillsets that ensure faster, more accurate support for consumers nationwide.

“Our mission is to make every customer feel supported, informed, and valued,” said a Samsung Customer Care spokesperson. “By investing heavily in technician training and service innovation, we’re delivering the highest standard of care-every time and everywhere.”

Bradford Custom Homes and Remodeling

Next up in this exciting episode, viewers learn about Bradford Custom Homes and Remodeling, a leading Southeastern luxury homebuilder, bringing viewers inside its purpose-driven and wellness-minded approach to creating legacy-grade homes. Known for timeless architecture, intentional design, and healthier living environments, Bradford builds for families who want their homes to perform at the level they aspire to perform.

Through thoughtful planning, craftsmanship, and a deep client-first philosophy, Bradford integrates wellness features such as cleaner air, better water, and circadian-supportive lighting that elevate daily living and long-term wellbeing.

“Luxury is more than finishes, it’s the responsibility to build homes that support the people who live in them,” said Brad Robinson, President of Bradford Custom Homes and Remodeling. “Our episode on “Trending Today” offers a rare behind-the-scenes look at how our values drive every decision we make.”

LegalEASE

The episode concludes with LegalEASE, one of the nation’s most trusted providers of legal benefits for employer groups. With more than 50 years of experience and a nationwide network of credentialed attorneys, LegalEASE is making legal support more accessible, understandable, and empowering for employees across the country.

Viewers will learn how LegalEASE’s proprietary matching system, tailored Legal Access Plans, and hands-on guidance help individuals navigate life’s biggest challenges from real estate transactions and family law to identity theft, estate planning, and financial disputes.

At the center of LegalEASE’s continued innovation is CEO Bob Heston, a recognized pioneer in the legal benefits industry whose vision has redefined how individuals access legal protection.

“Our goal is simple: make legal benefits practical, empowering, and easy to understand,” said Jason Weekley of LegalEASE. “Being featured on ‘Trending Today’ allows us to share how we’re reshaping the way employees engage with legal services.

The three companies showcased in the November 23 episode on Fox Business will also be featured on the “Trending Today” Podcast, available on Spotify, Apple Podcasts, Overcast, and all major streaming platforms.

To learn more, visit www.trendingtoday.com.

About ‘Trending Today’

“Trending Today,” the acclaimed television series airing on A&E, Bloomberg, and Fox Business, captures the entrepreneurial ambition that drives innovation around the world. Each episode highlights the latest technologies, market trends, and groundbreaking ideas through a thoughtfully selected lineup of inventors, innovators, and thought leaders. Covering a wide range of industries, including consumer products, luxury lifestyles, wellness, real estate, and technology, “Trending Today” features companies pushing boundaries and redefining excellence. To learn more, visit www.trendingtoday.com.

Contact

Liz Plummer
Executive Producer, Trending Today
Liz@trendingtoday.com

SOURCE: Trending Today

View the original press release on ACCESS Newswire

ORLANDO, FLORIDA / ACCESS Newswire / November 21, 2025 / RedChip Companies will air interviews with NioCorp Developments Ltd. (Nasdaq:NB) and FatPipe, Inc. (Nasdaq:FATN) on the RedChip Small Stocks, Big Money^™ show, a sponsored program on Bloomberg TV this Saturday, November 22, at 7 p.m. Eastern Time (ET). Bloomberg TV is available in an estimated 73 million homes across the U.S.

Access the interviews in their entirety at:

• NB: https://www.redchip.com/assets/access/nb_access

• FATN: https://www.redchip.com/assets/access/fatn_access

In an exclusive interview, Mark A. Smith, CEO of NioCorp, will appear on the RedChip Small Stocks Big Money^™ show on Bloomberg TV to discuss how the NioCorp is advancing the Elk Creek Critical Minerals Project, a fully permitted U.S. source of niobium, scandium, titanium, and magnetic rare earth elements essential to advanced manufacturing and national security. Designed to become one of America’s most important domestic suppliers of critical minerals, Elk Creek has already secured $10 million in Pentagon funding and is currently under review by the U.S. Export-Import Bank for up to $780 million in potential project financing. Mr. Smith will also highlight NioCorp’s partnerships with tier-one customers and strategic collaborators-including Lockheed Martin’s Skunk Works® division-as well as the company’s strong financial position, recent capital raises, and its role in helping the U.S. reduce reliance on foreign mineral supply chains tied to defense, aerospace, EVs, robotics, and clean energy markets.

Dr. Ragula Bhaskar, CEO and Co-Founder of FatPipe, appears on the RedChip Small Stocks Big Money^™ show on Bloomberg TV to discuss the company’s pioneering innovations in software-defined wide area networking (SD-WAN) and next-generation cybersecurity. Under Dr. Bhaskar’s leadership, FatPipe has evolved from an SD-WAN pioneer-credited with creating the category itself-to a leader in delivering advanced, cost-effective network security solutions for small and mid-sized businesses. He will highlight FatPipe’s patented technologies that enable seamless, high-speed data transmission across multiple links and its new single-stack cybersecurity platform that provides enterprise-grade protection at SMB-friendly costs. Dr. Bhaskar will also discuss FatPipe’s global customer footprint, strong intellectual property portfolio, and growth strategy as the company expands its cybersecurity offerings to meet the escalating demand for secure, resilient connectivity in the hybrid workplace era.

NB and FATN are clients of RedChip Companies. Please read our full disclosure at https://www.redchip.com/legal/disclosures.

About NioCorp

NioCorp is developing the Elk Creek Project that is expected to produce niobium, scandium, and titanium. The Company also is evaluating the potential to produce several rare earths from the Elk Creek Project. Niobium is used to produce specialty alloys as well as High Strength, Low Alloy steel, which is a lighter, stronger steel used in automotive, structural, and pipeline applications. Scandium is a specialty metal that can be combined with Aluminum to make alloys with increased strength and improved corrosion resistance. Scandium is also a critical component of advanced solid oxide fuel cells. Titanium is used in various lightweight alloys and is a key component of pigments used in paper, paint and plastics and is also used for aerospace applications, armor, and medical implants. Magnetic rare earths, such as neodymium, praseodymium, terbium, and dysprosium are critical to the making of neodymium-iron-boron magnets, which are used across a wide variety of defense and civilian applications.

About FatPipe, Inc.

FatPipe pioneered the concept of software-defined wide area networking (SD-WAN) and hybrid WANs that eliminated the need for cooperation from ISPs and allow companies and service providers to control multi-link network traffic worldwide. FatPipe has now pioneered cost-effective, advanced single-stack cybersecurity for on-premise deployments that significantly improve network and cybersecurity for SMBs. For more information, please visit www.fatpipeinc.com.

About RedChip Companies

RedChip Companies, an Inc. 5000 company, is an international investor relations, media, and research firm focused on microcap and small-cap companies. Founded in 1992 as a small-cap research firm, RedChip gained early recognition for initiating coverage on emerging blue chip companies such as Apple, Starbucks, Daktronics, Winnebago, and Nike. Over the past 33 years, RedChip has evolved into a full-service investor relations and media firm, delivering concrete, measurable results for its clients, which have included U.S. Steel, Perfumania, Cidara Therapeutics, and Celsius Holdings, among others. Our newsletter, Small Stocks, Big Money^™, is delivered online weekly to 60,000 investors. RedChip has developed the most comprehensive service platform in the industry for microcap and small-cap companies. These services include the following: a worldwide distribution network for its stock research; retail and institutional roadshows in major U.S. cities; outbound marketing to stock brokers, RIAs, institutions, and family offices; a digital media investor relations platform that has generated millions of unique investor views; investor webinars and group calls; a television show, Small Stocks, Big Money^™, which airs weekly on Bloomberg US; TV commercials in local and national markets; corporate and product videos; website design; and traditional investor relation services, which include press release writing, development of investor presentations, quarterly conference call script writing, strategic consulting, capital raising, and more. RedChip also offers RedChat^™, a proprietary AI-powered chatbot that analyzes SEC filings and corporate disclosures for all Nasdaq and NYSE-listed companies, giving investors instant, on-demand insights.

To learn more about RedChip’s products and services, please visit:

https://www.redchip.com/corporate/investor_relations

“Discovering Tomorrow’s Blue Chips Today”^™

Follow RedChip on LinkedIn: https://www.linkedin.com/company/redchip/

Follow RedChip on Facebook: https://www.facebook.com/RedChipCompanies

Follow RedChip on Instagram: https://www.instagram.com/redchipcompanies/

Follow RedChip on Twitter: https://twitter.com/RedChip

Follow RedChip on YouTube: https://www.youtube.com/@redchip

Follow RedChip on Rumble: https://rumble.com/c/c-3068340

Subscribe to our Mailing List: https://www.redchip.com/newsletter/latest

Contact:

Dave Gentry
RedChip Companies Inc.
1-800-REDCHIP (733-2447)
1-407-644-4256
info@redchip.com

–END–

SOURCE: RedChip Companies, Inc.

View the original press release on ACCESS Newswire

The Cavorite X7 is designed to fly safely in clouds and known icing conditions at faster speeds and lower operating costs than helicopters, aiming for undisrupted flight operations worldwide

TORONTO, ONTARIO / ACCESS Newswire / November 21, 2025 / New Horizon Aircraft Ltd. (NASDAQ:HOVR), doing business as Horizon Aircraft (“Horizon Aircraft” or the “Company”), an advanced aerospace engineering company and developer of one of the world’s first hybrid electric VTOL (Vertical Take-Off and Landing) aircraft, continues its progress in building its Cavorite X7 to fly under Instrument Flight Rules (IFR) allowing the aircraft to fly in clouds, a differentiating feature no other eVTOL has achieved. The Cavorite X7 is also being built to certify for Flight Into Known Icing (FIKI), both certifications held by only a small handful of expensive, heavyweight helicopters. The Cavorite X7 aims to be able to fly critical missions such as medevac, search and rescue, and critical goods delivery reliably and year-round, with enhanced safety, speed, and lower operating costs.

With an ability to get in and out of difficult and inaccessible locations, helicopters serve many crucial functions. However, a helicopter’s exposed rotor blades are susceptible to ice formation that can cause damage, severe instability, and loss of lift. These significant safety risks result in flight cancellations, a hold on emergency dispatch, and for the Canadian Coast Guard, interruptions and failures of marine aids to navigation.

“As a seasoned commercial helicopter pilot, I have experienced firsthand how known icing conditions can force delays, cancellations, and operational setbacks,” stated Horizon Aircraft Senior Technical Project Manager, Vincent Hoog. “I joined Horizon Aircraft because the technology on the Cavorite X7 provides a real solution to these problems, and its enhanced performance will be able to serve more people and communities worldwide when they need it most.”

This month, the Company kicked off its collaborative all-weather vertical propulsion project that was recently awarded a non-dilutive grant from Canada’s INSAT program (The Initiative for Sustainable Aviation Technology). Advanced ice detection and protective technologies such as ice-phobic and electrothermal coating solutions will be tested on the Cavorite X7, preparing the aircraft to be certified to fly under IFR and in FIKI conditions.

Horizon Aircraft Co-Founder and CEO, Brandon Robinson stated, “The Cavorite X7 is one of the only modern VTOL aircraft designed to fly in clouds. This significant differentiator will provide all-weather operations with improved performance for all real-world operations. Horizon is currently building our full-scale aircraft and has secured sufficient capital and scaled our engineering team by 50% this year to be ready for testing.”

For more information about Horizon Aircraft, please see the Company’s website or watch its innovative technology in action on the Company’s YouTube channel.

About Horizon Aircraft

Horizon Aircraft (NASDAQ:HOVR) is an advanced aerospace engineering company that is developing one of the world’s first hybrid electric VTOLs designed to fly most of its mission exactly like a normal aircraft while offering industry-leading speed, range, and operational utility. Horizon Aircraft’s unique designs put the mission first and prioritize safety, performance, and utility. Horizon Aircraft intends to successfully complete testing and certification of its Cavorite X7 hybrid electric VTOL and then scale unit production to meet expected demand from regional operators, emergency service providers, and military customers.

For further information, visit:

Website www.horizonaircraft.com
LinkedIn https://www.linkedin.com/company/horizon-aircraft-inc

For further information, contact:

Investors:

Matt Chesler, CFA
FNK IR LLC
(646) 809-2183
HOVR@fnkir.com

Media:

Edwina Frawley-Gangahar
EFG Media Relations
+44 7580 174672
edwina@efgmediarelations.com

Forward-Looking Statements

This press release contains certain “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995 and “forward-looking information” within the meaning of applicable Canadian securities laws (collectively, “forward-looking statements”). These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “aim,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “target,” “will be,” “will continue,” “will likely result” and similar expressions, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements herein include, but are not limited to, statements relating to the targeted readiness of the full-scale hybrid Cavorite X7 eVTOL prototype for initial testing, development priorities and technical milestones; funding and liquidity sufficiency and runway; certification and testing plans; and potential production, partnership, supply chain and market opportunities.

Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Actual results may differ from their expectations, estimates and projections and consequently, you should not rely on these forward-looking statements as predictions of future events. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, including but not limited to: (i) changes in the markets in which Horizon Aircraft competes, including with respect to its competitive landscape, technology evolution or regulatory changes; (ii) the risk that Horizon Aircraft will need to raise additional capital to execute its business plans, which may not be available on acceptable terms or at all; (iii) the lack of useful financial information for an accurate estimate of future capital expenditures and future revenue; (iv) statements regarding Horizon Aircraft’s industry and market size; (v) financial condition and performance of Horizon Aircraft, including the condition, liquidity, results of operations, the products, the expected future performance and market opportunities of Horizon Aircraft; (vi) Horizon Aircraft’s ability to develop, certify, and manufacture an aircraft that meets its performance expectations; (vii) successful completion of testing and certification of Horizon Aircraft’s Cavorite X7 eVTOL; (viii) the targeted future production of Horizon Aircraft’s Cavorite X7 aircraft; and (ix) other factors detailed by us in the Company’s public filings with the Securities and Exchange Commission (“SEC”) and under the Company’s profile on sedarplus.ca, including the disclosures under the heading “Risk Factors” in the Company’s Annual Report on Form 10-K for the fiscal year ended May 31, 2025, filed with the SEC and filed under the Company’s profile on sedarplus.ca on August 22, 2025. These filings identify and address other important risks and uncertainties that could cause actual events and results to differ materially from those contained in the forward-looking statements. Forward-looking statements speak only as of the date they are made.

Readers are cautioned not to put undue reliance on forward-looking statements, and while the Company may elect to update these forward-looking statements at some point in the future, it assumes no obligation to update or revise these forward-looking statements, whether as a result of new information, future events, or otherwise, unless required by applicable law. Horizon Aircraft does not give any assurance that Horizon Aircraft will achieve its expectations.

SOURCE: Horizon Aircraft

View the original press release on ACCESS Newswire

Launch of the FaZe Esports Pass ushers in a new era of fan engagement by merging gaming culture, collectibles, and community into one ecosystem.

FRISCO, TEXAS / ACCESS Newswire / November 21, 2025 / GameSquare Holdings, Inc. (“GameSquare” or the “Company”) (NASDAQ:GAME), a next-generation media, entertainment, and technology company, today announced the launch of the FaZe Esports Pass, an all-access digital membership developed in partnership with Clout, an emerging fan-engagement platform transforming how audiences connect with the brands, teams, and creators they love.

The FaZe Esports Pass, located on the Clout platform, introduces a new, scalable digital product designed to deepen fan engagement, expand recurring revenue streams, and unlock a long-term, gamified marketplace for FaZe fans worldwide. The FaZe Esports Pass gives fans access to exclusive rewards, challenges, and benefits through a gamified setting, allowing users to progress through a battlepass-styled marketplace for real rewards and unique drops.

Season 1 runs through February 18th, 2026. Fans can sign up for the FaZe Esports Pass Clout platform (available on iOS, and Android).

“The FaZe Esports Pass and our partnership with Clout mark major milestones in executing our digital strategy and building scalable, high-margin products across the GameSquare ecosystem,” said Justin Kenna, CEO of GameSquare. “The FaZe Esports Pass is purpose-built for today’s fan offering an interactive, gamified, and reward-driven online experience. It expands our monetization opportunities, strengthens the FaZe Esports brand, and creates a new repeatable product framework we can extend into other GameSquare properties, teams, and partners.”

“The FaZe Esports Pass represents the next evolution of fan engagement, and we’re excited to bring this to fans on Clout,” said Stu Porter, CEO of Clout. “Fans have always wanted to be part of the story and rewarded for their engagement. Now they can play, earn, and collect inside an experience built entirely for them.”

The FaZe Esports Pass expands GameSquare’s growing portfolio of owned digital products and fan monetization channels. It provides:

• A new recurring digital revenue stream through season-based memberships

• A scalable foundation for future brand integrations across GameSquare’s ecosystem

• High-margin digital rewards and low-friction onboarding for fans

• A direct engagement layer between FaZe Esports and millions of fans worldwide

Future seasons will introduce new collaborations, partner integrations, reward tiers, and expanded cross-ecosystem features powered by GameSquare’s growing technology infrastructure.

About Clout

Clout gamifies fandom by turning engagement into real rewards. Fans engage, compete, earn XP & coins, and redeem marketplace prizes while connecting with the teams, brands, and creators they love most. Built for fans and powered by community, Clout’s mission is to reward fan engagement and redefine participation in the online culture, gaming and sports ecosystem. For more information – visit www.playclout.gg.

About FaZe Esports

FaZe Esports is the competitive arm of the FaZe organization, representing one of the most recognized names in global esports. Known for its championship teams and impact across titles like Counter-Strike, Call of Duty, and Fortnite, FaZe Esports continues to shape the future of competitive gaming and fan-driven entertainment.

About GameSquare Holdings, Inc.

GameSquare (NASDAQ: GAME) is a cutting-edge media, entertainment, and technology company transforming how brands and publishers connect with Gen Z, Gen Alpha, and Millennial audiences. With a platform that spans award-winning creative services, advanced analytics, and FaZe Esports, one of the most iconic gaming organizations, we operate one of the largest gaming media networks in North America. As a digital-native business, GameSquare provides brands with unparalleled access to world-class creators and talent, delivering authentic connections across gaming, esports, and youth culture. Complementing our operating strategy, GameSquare has developed an innovative treasury management program designed to generate yield and enhance capital efficiency, reinforcing our commitment to building a dynamic, high-performing media company at the intersection of culture, technology, and next-generation financial innovation.

To learn more, visit www.gamesquare.com.

Forward-Looking Information

This news release contains “forward-looking information” and “forward-looking statements” (collectively, “forward-looking statements”) within the meaning of the applicable securities legislation. All statements, other than statements of historical fact, are forward-looking statements and are based on expectations, estimates and projections as at the date of this news release. Any statement that involves discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, assumptions, future events or performance (often but not always using phrases such as “expects”, or “does not expect”, “is expected”, “anticipates” or “does not anticipate”, “plans”, “budget”, “scheduled”, “forecasts”, “estimates”, “believes” or “intends” or variations of such words and phrases or stating that certain actions, events or results “may” or “could”, “would”, “might” or “will” be taken to occur or be achieved) are not statements of historical fact and may be forward-looking statements. In this news release, forward-looking statements relate, among other things, to: the Company’s future performance, returns generated by its business strategies, revenue, growth and profitability; and the Company’s ability to execute on its current and future business plans. These forward-looking statements are provided only to provide information currently available to us and are not intended to serve as and must not be relied on by any investor as, a guarantee, assurance or definitive statement of fact or probability. Forward-looking statements are necessarily based upon a number of estimates and assumptions which include, but are not limited to: the Company’s ability to grow its business and being able to execute on its business plans and strategies, the success of Company’s vendors and partners in their provision of services to the Company, the Company being able to recognize and capitalize on opportunities and the Company continuing to attract qualified personnel to support its development requirements. These assumptions, while considered reasonable, are subject to known and unknown risks, uncertainties, and other factors which may cause the actual results and future events to differ materially from those expressed or implied by such forward-looking statements. Such factors include, but are not limited to: the Company’s annual meeting and corporate governance, its ability to achieve its objectives, the Company successfully executing its growth strategy, the ability of the Company to obtain future financings or complete offerings on acceptable terms, failure to leverage the Company’s portfolio across entertainment and media platforms, dependence on the Company’s key personnel and general business, economic, competitive, political and social uncertainties.

These risk factors are not intended to represent a complete list of the factors that could affect the Company which are discussed in the Company’s most recent MD&A. There can be no assurance that forward-looking statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on the forward-looking statements and information contained in this news release. GameSquare assumes no obligation to update the forward-looking statements of beliefs, opinions, projections, or other factors, should they change, except as required by law.

Corporate Contact Lou Schwartz, President Phone: (216) 464-6400 Email: ir@gamesquare.com

Investor Relations Andrew Berger Phone: (216) 464-6400 Email: ir@gamesquare.com

Media Relations Alana Battaglia / The Untold Email: pr@gamesquare.com

SOURCE: GameSquare Holdings, Inc.

View the original press release on ACCESS Newswire

Findings expand Telomir-1’s oncology profile into cancers of the blood, adding to previously reported activity in triple-negative breast, pancreatic, and aggressive prostate cancer models.

MIAMI, FL / ACCESS Newswire / November 21, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) (“Telomir” or the “Company”), a preclinical-stage biotechnology company developing small-molecule therapies targeting the epigenetic and metabolic roots of cancer, aging, and age-related disease, today announced new in vitro findings showing that its investigational compound Telomir-1 kills aggressive human leukemia (HL60) cells.

In this study, HL60 leukemia cells were treated with Telomir-1, which produced a clear, dose-dependent reduction in viable leukemia cells, indicating strong activity in this aggressive human model.

Leukemia: A Disease with Persistent Treatment Challenges

Leukemia is a cancer of the blood and bone marrow defined by the uncontrolled growth of abnormal white blood cells. It remains one of the most difficult cancers to treat, with more than 60,000 new cases diagnosed each year in the United States and an estimated 487,294 new cases globally, according to the World Cancer Research Fund (WCRF).

Despite therapeutic progress, several major biological challenges remain:

• High relapse rates:
  Many patients respond initially but relapse as treatment-resistant leukemia cells re-expand.

• Resistance to current treatments:
  Leukemia cells frequently develop resistance to chemotherapy, targeted agents-including FLT3 and IDH inhibitors-and BCL-2-based regimens such as venetoclax, enabling surviving clones to repopulate the bone marrow and blood.

• Toxicity of existing therapies:
  Current treatments often damage healthy blood and immune cells, increasing infection risk and reducing quality of life.

• Epigenetic and metabolic adaptability:
  Leukemia blast and stem cells rely on altered metabolic states and epigenetic silencing to evade therapy and re-establish disease.

• Limited treatment options for older or medically fragile patients:
  Many cannot tolerate intensive regimens, leaving meaningful unmet medical need.

These challenges highlight the importance of scientific approaches aimed at understanding the underlying biology that allows leukemia cells to grow, proliferate, survive, and resist treatment.

Iron Dependence and Epigenetic Silencing: Why Leukemia Cells May Be Vulnerable to Telomir-1

Leukemia cells rely heavily on iron as a fuel source to support rapid DNA synthesis, mitochondrial energy production, and uncontrolled proliferation. Many leukemia subtypes increase iron uptake and accumulate excess intracellular iron, creating a metabolic environment that supports tumor growth. Elevated iron also powers iron-dependent epigenetic enzymes that leukemia cells use to silence tumor-suppressor genes-genes that normally regulate growth, promote apoptosis, or assist immune detection. Together, iron overload and epigenetic silencing form two of leukemia’s central biological survival strategies.

In previously reported research, Telomir-1 demonstrated the ability to reduce intracellular iron levels in a live-cell human model, where fluorescence imaging with FerroOrange showed a robust, concentration-dependent reduction in ferrous iron (Fe²⁺) relative to the FDA-approved iron chelator Deferoxamine (DFO). These findings confirmed Telomir-1’s intracellular penetration and iron-modulating activity at low micromolar concentrations. Because leukemia cells depend so heavily on iron, this type of intracellular iron modulation may be relevant to understanding how cancer cells respond to Telomir-1.

Leukemia cells also frequently silence key tumor-suppressor pathways through abnormal DNA methylation and iron-dependent histone demethylases. Although the current leukemia study measured cytotoxicity only, Telomir-1 has previously been shown in a cancer model to reverse hypermethylation of several tumor-suppressor genes-including STAT1, CDKN2A, MASPIN, RASSF1A, CASP8, and GSTP1-genes involved in immune surveillance, apoptosis, detoxification, and cell-cycle braking. These findings demonstrate Telomir-1’s ability to influence epigenetic programs that many cancers, including leukemia, rely on for survival and treatment resistance. In addition, the recent findings that Telomir-1 inhibits three major families of lysin histone demethylase (KDMs) enzymes, belonging to the KDM2, KDM5 and KDM6, reinforce its potential in cancer treatment. KDMs are major epigenetic regulators that control histone methylation and thereby influence transcription, differentiation, and stemness. In leukemia, several KDMs become overexpressed, mutated, or integrated into oncogenic complexes, driving leukemogenesis.

Through Telomir’s preclinical research, Telomir-1 has demonstrated activity across pathways involving iron handling, oxidative balance, and epigenetic regulation. The leukemia results add to this growing body of scientific evidence and extend it into cancers of the blood.

Part of Telomir’s Broader Oncology Research

The new leukemia findings join a growing set of preclinical research observations:

Triple-Negative Breast Cancer (TNBC):
Telomir-1 caused a strong, dose-dependent loss of TNBC cell viability that was reversible by iron re-addition.

Pancreatic Cancer:
Telomir-1 reduced pancreatic-cancer cell survival and mitochondrial activity, with partial reversal by iron.

Aggressive Prostate Cancer (PC3 Model):
In vivo studies demonstrated reduced tumor volume and reversal of abnormal DNA methylation across multiple tumor-suppressor genes.

Each cancer model has provided distinct insights into the biological pathways influenced by Telomir-1, supporting a consistent scientific framework for its evaluation across oncology.

CEO Commentary

Erez Aminov, Chief Executive Officer of Telomir Pharmaceuticals, stated:
“Many of the most aggressive cancers share two fundamental biological drivers: dysregulated iron that fuels uncontrolled growth and abnormal DNA methylation that silences the genes responsible for protecting the body against cancer. Our goal with Telomir-1 is to address these upstream processes at their source. By influencing pathways involved in intracellular iron balance and epigenetic control, Telomir-1 represents a truly novel category of therapy-one designed to work with the body’s natural defenses rather than simply targeting downstream symptoms. We believe this approach may signal the beginning of a new era in oncology research, where resetting the underlying biology becomes as important as treating the disease itself.”

Scientific Commentary

Dr. Itzchak Angel, Chief Scientific Advisor, added:
“The potency observed in HL60 leukemia cells is consistent with the broader biological patterns we have seen throughout Telomir’s research. Telomir-1 has demonstrated activity across pathways connected to iron imbalance and epigenetic disruption-both central features of tumor biology. These findings support our scientific framework for evaluating Telomir-1 and inform the ongoing advancement of our overall oncology research program.”

About Telomir Pharmaceuticals

Telomir Pharmaceuticals (NASDAQ:TELO) is a preclinical biotechnology company developing small-molecule therapeutics that target the root epigenetic mechanisms underlying cancer, aging, and degenerative disease. The Company’s lead candidate, Telomir-1, has demonstrated activity in preclinical studies involving modulation of DNA and histone methylation, restoration of redox balance, and normalization of cellular function.
For more information, please visit www.telomirpharma.com.

Cautionary Note Regarding Forward-Looking Statements

This press release, statements of Telomir’s management or advisors related thereto, and the statements contained in the news story linked in this release contain “forward-looking statements,” which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications, and the safety of Telomir-1.

Any forward-looking statements in this press release are based on Telomir’s current expectations, estimates and projections only as of the date of this release. These and other risks concerning Telomir’s programs and operations are described in additional detail in its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, which are on file with the SEC and available at www.sec.gov. Telomir explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.

Contact Information

Helga Moya
info@telomirpharma.com
(786) 396-6723

SOURCE: Telomir Pharmaceuticals, Inc

View the original press release on ACCESS Newswire