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MIRA advances Ketamir-2 in the clinic for neuropathic pain while broadening development into neuropsychiatric disorders such as PTSD

MIAMI, FLORIDA / ACCESS Newswire / September 16, 2025 / MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA) (“MIRA” or the “Company”), a clinical-stage pharmaceutical company developing novel oral therapeutics for neurologic, neuropsychiatric, and metabolic disorders, today announced positive results demonstrating that its oral drug candidate Ketamir-2 restored normalized behavior in stressed animals within a validated model of post-traumatic stress disorder (PTSD). Ketamir-2 is currently being evaluated in an ongoing Phase 1 clinical trial for neuropathic pain, where it has shown a favorable safety profile to date.

“Restoring behavior to normal in a stressed PTSD model represents an important step forward,” said Erez Aminov, CEO of MIRA Pharmaceuticals. “These findings support our decision to broaden the scientific evaluation of Ketamir-2 beyond neuropathic pain into neuropsychiatric disorders such as PTSD. Looking ahead, we plan to explore opportunities for potential collaborations, including with military and government institutions, given the significant unmet need for effective PTSD treatments.”

This proof-of-concept validation study was conducted in a small group of rats using the Single Prolonged Stress (SPS) model, a widely accepted paradigm for inducing inescapable stress that mimics PTSD symptoms in animals. Animals were exposed twice to a predator stressor (bobcat urine), which is known to induce “depression-like” symptoms and changes in active/passive coping. Increased immobility after stress exposure reflects enhanced affective impairment or reduced stress resilience. Following the development of these symptoms, animals were dosed orally with Ketamir-2 once daily for five consecutive days.

Behavioral assessments included anxiety- and coping/resilience-related behavior in the forced swim test (FST), which measures immobility versus active coping strategies.

Outcome: stressed animals displayed hallmark PTSD-like behaviors, including increased despair, immobility, and avoidance of coping. Treatment with Ketamir-2 reversed these types of behaviors, restoring them toward the level observed in non-stressed animals. This initial validation supports the study design, and a larger follow-on PTSD study is ongoing.

“These preliminary results reinforce the therapeutic potential of Ketamir-2 in PTSD,” said Dr. Itzchak Angel, Chief Scientific Advisor of MIRA. “We observed consistent reversal of stress-induced behavioral changes, supporting continued investigation of Ketamir-2 across neuropsychiatric disorders.”

PTSD: A Major Unmet Need

• PTSD affects an estimated 13 million adults in the United States each year, with approximately 6% of U.S. adults experiencing PTSD at some point in their lives.

• The economic and social burden of PTSD is estimated at $232 billion annually in the U.S., driven by lost productivity, medical care, and disability.

• The treatment landscape is limited:

  • Only two FDA-approved medications exist for PTSD (sertraline and paroxetine, both SSRIs), which provide limited relief and are often poorly tolerated (FDA PTSD treatments).

  • Psychotherapies such as CBT and EMDR can be effective, but access, adherence, and dropout rates remain significant challenges.

• The U.S. Department of Defense and Veterans Affairs continue to invest heavily in novel PTSD research, underscoring the urgent need for safer and more effective solutions for service members and veterans.

About Ketamir-2

Ketamir-2 is a proprietary, orally bioavailable new molecular entity that selectively targets the NMDA receptor (PCP site) with low affinity and demonstrates no significant off-target activity across a broad receptor panel. Ketamir-2 was designed to capture the therapeutic efficacy of ketamine while minimizing the unwanted dissociative and other central nervous system side effects that limit ketamine’s clinical use. The U.S. Drug Enforcement Administration’s scientific review of Ketamir-2 concluded that it would not be considered a controlled substance or listed chemical under the Controlled Substances Act and its governing regulations. Previous animal studies have also shown Ketamir-2’s superior efficacy versus ketamine, pregabalin, and gabapentin in neuropathic pain models.

Cautionary Note Regarding Forward-Looking Statements

This press release and the statements of MIRA’s management related thereto contain “forward-looking statements,” which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will,” and variations of these words or similar expressions that are intended to identify forward-looking statements. Any statements in this press release that are not historical facts may be deemed forward-looking. Any forward-looking statements in this press release are based on MIRA’s current expectations, estimates, and projections only as of the date of this release and are subject to a number of risks and uncertainties (many of which are beyond MIRA’s control) that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements, including related to MIRA’s potential merger with SKNY Pharmaceuticals, Inc. These and other risks concerning MIRA’s programs and operations are described in additional detail in the Annual Report on Form 10-K for the year ended December 31, 2024, and the Form 14A filed by MIRA on June 18, 2025, and other SEC filings, which are on file with the SEC at www.sec.gov and on MIRA’s website at https://www.mirapharmaceuticals.com/investors/sec-filings. MIRA explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.

Contact:
Helga Moya
info@mirapharma.com
(786) 432-9792

SOURCE: MIRA Pharmaceuticals

View the original press release on ACCESS Newswire

MILTON, ON / ACCESS Newswire / September 16, 2025 / Pro-1 Truck Repair & Tires, a trusted service provider specializing in comprehensive truck and trailer repair, has been named the 2025 Consumer Choice Award recipient in the Truck Service and Repair category for Halton. Recognized for its commitment to quality workmanship, competitive pricing, and reliable roadside support, Pro-1 has quickly become a go-to destination for drivers and fleets across the region.

Since opening in 2019, Pro-1 Truck Repair & Tires has built its reputation on providing efficient, expert repair services for all types of trucks and RVs. The shop specializes in car haulers, flatbeds with low decks, and goosenecks, while also servicing highway trucks, vans, and reefer trailers. Conveniently located off Exit 320 on Highway 401 in Acton/Milton, the shop offers easy access for local and passing drivers in need of quick, dependable service.

“At Pro-1, we know the importance of keeping trucks on the road,” says the Pro-1 Truck Repair team. “Downtime costs drivers and businesses valuable time and money, and our mission is to deliver expert repairs and fast solutions so our clients can get back to work with confidence.”

Expertise That Drivers Trust

Pro-1’s success lies in its focus on delivering more than just mechanical fixes-it’s about providing peace of mind. The skilled team works across a wide range of vehicles and equipment, from heavy-duty highway rigs to specialized trailers. Whether it’s routine maintenance, urgent repair, or roadside assistance, Pro-1 has earned the trust of drivers who depend on reliable service and honest pricing.

The company’s roadside service further sets it apart, ensuring drivers can access expert support when and where they need it most. This level of commitment has made Pro-1 a vital partner for both independent operators and commercial fleets.

“We take pride in offering not only excellent repair services but also fair and competitive pricing,” adds the Pro-1 team. “Our goal is to keep every customer satisfied and every truck running smoothly.”

Recognition Backed by Research

The Consumer Choice Award is the only award in North America that recognizes business excellence based on independent market research. There are no panels or public votes-winners are chosen strictly through unbiased studies of consumer perceptions and brand reputation.

For Pro-1 Truck Repair & Tires, this recognition is a reflection of its unwavering dedication to service, reliability, and customer trust. In just a few short years, the business has established itself as a leader in the Halton region’s truck service industry.

Looking Ahead

As the demand for reliable truck repair services grows, Pro-1 Truck Repair & Tires remains focused on expanding its capabilities while staying true to its roots: expert repair, responsive service, and a customer-first approach. With roadside assistance and a central location serving the busy 401 corridor, the company is well positioned to continue meeting the evolving needs of the trucking community.

To learn more about Pro-1 Truck Repair & Tires or to book service, Click Here.

About Pro-1 Truck Repair & Tires
Founded in 2019, Pro-1 Truck Repair & Tires is a leading truck service provider located off Exit 320 on Highway 401 in Acton/Milton. Specializing in car haulers, flatbeds, goosenecks, highway trucks, vans, and reefer trailers, the company offers comprehensive repair solutions and reliable roadside services at competitive prices.

About Consumer Choice Award
Since 1987, Consumer Choice Award has been recognizing and promoting business excellence across North America. Through a rigorous selection process, only the most outstanding businesses in each category earn this prestigious recognition. Learn more at www.ccaward.com.

Contact Information:
Sumi Saleh
Communications Manager
ssaleh@ccaward.com

SOURCE: Consumer Choice Award

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iAccess Alpha’s Virtual Best Ideas Fall Investment Conference September 16-17, 2025

RALEIGH, NC / ACCESS Newswire / September 16, 2025 / iAccess Alpha’s Virtual Best Ideas Fall Investment Conference will take place on September 16-17, 2025, bringing together top micro-cap companies and investors for two days of high-quality insights and investing opportunities.

The event begins on Tuesday, September 16, 2025, with a series of live-streamed company presentations, beginning at 9:00 AM ET. The following day, Wednesday, September 17, will be dedicated to 1×1 meetings between presenting companies and pre-approved investors, starting at 8:00 AM ET.

How to Attend:
Investors and industry professionals can register to watch the presentations and request 1×1 meetings by visiting the official event website: Register Here

Conference Schedule – September 16, 2025 (All Times ET):

Time	Company	Ticker	Webcast Link
9:00am	NN, Inc.	NASDAQ:NNBR	View Presentation
9:30am	Xtract One Technologies Inc.	OTCQX:XTRAF / TSX:XTRA	View Presentation
10:00am	Health In Tech Inc.	NASDAQ:HIT	View Presentation
10:30am	Callan JMB Inc.	NASDAQ:CJMB	View Presentation
11:00am	Orion Energy Systems Inc.	NASDAQ:OESX	View Presentation
11:30am	Ascent Industries Co.	NASDAQ:ACNT	View Presentation
12:00pm	TOMI Environmental Solutions Inc	NASDAQ:TOMZ	View Presentation
12:30pm	RenovoRx Inc.	NASDAQ:RNXT	View Presentation
1:00pm	Alliance Entertainment Holding Corporation	NASDAQ:AENT	View Presentation
1:30pm	Peraso Inc.	NASDAQ:PRSO	View Presentation
2:00pm	P3 Health Partners Inc.	NASDAQ:PIII	View Presentation
2:30pm	SKYX Platforms Corp.	NASDAQ:SKYX	View Presentation
3:00pm	Perfect Moment Ltd.	NYSE/AMEX:PMNT	View Presentation
3:30pm	Sky Harbour Group Corp.	NYSE:SKYH	View Presentation

About iAccess Alpha’s Virtual Best Ideas Investment Conferences
iAccess Alpha hosts four virtual investment conferences annually (March, June, September, and December), showcasing high-potential small and micro-cap investment opportunities. The conferences feature live company presentations on Day 1, followed by exclusive 1×1 investor meetings on Day 2. Since 2019, iAccess Alpha has co-organized leading microcap-focused events, connecting top-tier investors with high-potential companies.

For more information, contact:
info@iaccessalpha.com
www.iaccessalpha.com

SOURCE: iAccess Alpha

View the original press release on ACCESS Newswire

The Digital Commerce Industry’s first agentic-native closed-loop learning platform that helps retailers, brands and agencies evaluate, enrich, distribute, and monitor their products on Agentic Commerce Engines such as ChatGPT, Google Gemini/AI Mode, Perplexity, Meta.ai, Microsoft Copilot, Grok and Claude.

RALEIGH, NC / ACCESS Newswire / September 16, 2025 / ReFiBuy today announced the general availability of its first product called Commerce Intelligence Engine.

“The ReFiBuy product team has been cooking, building a ground-up solution to the challenges Agentic Commerce presents to retailers, brands and agencies,” said Scot Wingo. “I also want to thank our ten design partners who gave us extremely valuable feedback in the last 90 days as we’ve been putting the finishing touches on the product.”

“ReFiBuy’s Commerce Intelligence Engine has accelerated our understanding of our readiness for Agentic shopping experiences and how GenAI understands our product catalog, “said Josh Krepon, President of US Direct to Consumer and Global Digital, Steve Madden. “The platform’s insights and actionable recommendations enhance our content and visibility for our GenAI digital shelf. The product-level GEO monitoring capabilities will play a key role in futureproofing for this new era of commerce.”

Commerce Intelligence Engine’s Core Six Capabilities

At the heart of the Commerce Intelligence Engine is ReFiBuy’s belief that everything in digital commerce starts and ends with the product catalog.

• Ingest – The Commerce Intelligence Engine starts with the ingestion of the brand or retailer’s product catalog. Our ingestion capability is built with ultimate flexibility pulling the product catalog from any existing system or using web data extraction.

• Evaluate – Evaluate reviews both catalog data and PDPs for each SKU, flagging GEO structural elements that cause Agentic Shopping Agent issues. Then Evaluate assesses titles, images, variations, and existing attributes, while also recommending missing attributes LLMs need for additional context. All findings are summarized in a scorecard across Content Quality, GEO Structure, LLM Semantic Quality, and User Experience.

• Enrich – Based on the customer’s feedback and approval from the Evaluate process, Enrich implements the suggested and approved changes at the product catalog level. The product catalog is now optimized to maximize Agentic Shopping Engine exposure.

• Sync – At any point in the process, customers can export their enriched product catalog to a variety of file formats, or route it directly into existing systems and workflows for further processing or approvals.

• Distribute – At the customer’s request, the Distribute capability delivers the now enriched product catalog to up to six different Agentic Shopping Engines including: ChatGPT, Gemini, Perplexity, Meta.ai, Microsoft Copilot, Grok and Claude.

• Monitor – The Commerce Intelligence Engine’s Monitor capability scans the six Agentic Shopping Engines and score’s a product across three criteria: visibility, data quality and AI Digital Shelf.

Evaluate Capability Details

Once ingested, the system evaluates both the site-structure at the PDP level and the product catalog data level for every SKU in the customer’s catalog.

At the PDP level, Evaluate looks at structural issues and makes recommendations that will optimize the PDP for Agentic Shopping Engine’s web crawlers, agents and agentic browsers to access all the product data, reviews and other information that gives the LLM context on the product. Common issues the system detects are stale/incorrect schema.org data, unintentional bot blockers, and the use of complex JavaScript elements that prevent the agents from ‘seeing’ product content.

At the product catalog level, Evaluate examines every data element of the product catalog (from all sources including PDP, data feed or legacy systems) such as titles, images, all variations and existing attributes. In addition to existing attributes, the Evaluate capability recommends incremental attributes to add to the product catalog to give Agentic Shopping Engines a more complete picture of the product’s capabilities, compatibilities, etc.

Evaluate then takes the recommendations from the PDP structure and the product catalog and produces a detailed per-product scorecard based on four criteria:

1. Product Content Quality – Is the existing PDP-level product catalog data content optimized for GenAI? Typical recommendations include adding more context, improving titles, enhancing existing attributes and adding missing attributes through our enrichment capability.

2. GEO Structure – Many retailer and brand sites have structural issues with bot blockers, bad metadata, incorrect or missing llms.txt and frequently schema.org is missing, outdated or has the wrong data.

3. LLM Semantic Quality – Assesses the semantic coherence and natural language understanding quality of the product descriptions.

4. User Experience – Measures the overall user interface, accessibility and interaction quality of the product page.

Monitor Capability Details

Called GEO by other vendors, instead of looking at high-level ‘sentiment’, the Monitor feature takes a subset sample of the customer’s product catalog, goes to out to seven Agentic Shopping Engines (ChatGPT, Gemini, Perplexity, Microsoft Copilot, Meta.ai, Grok and Claude), where it executes product-level prompts designed to replicate shopper behavior. Monitor then records screen shots of the Agentic Shopping Engines’ detailed responses

Monitor then evaluates each Agentic Shopping Engine’s product-level prompt response across three criteria:

• Visibility – Initially, due to bot blocking, structural problems and other issues, a large portion of a customer’s products are not even ‘indexed’ or trained on by the Agentic Shopping Engines. This is the pre-requisite for showing up at all.

• Data Quality – Once a product’s visibility has been verified and the product is being displayed by the Agentic Shopping Engine, Monitor verifies all the product information displayed is correct including: in-stock status, variation details, attributes, ratings are all being pulled in correctly, the correct images are shown, and the right product detail page link is provided to the agent or the human user. Also, all pricing information, any free shipping or other offers are verified to make sure the Agentic Shopping is presenting the shopper with the most compelling and competitive offer.

• AI Digital Shelf – Finally, Monitor evaluates each product’s ‘AI Digital Shelf’. ReFiBuy believes every retailer and brand’s goal should be to have their product ‘own the product card’ meaning that when the human or agent go to buy the product, they win the top spot, and the zero-sum game of the purchase. The AI Digital Shelf reports to the customer their relative position on the product card as well as total transparency around competitor’s positioning, pricing and how they are representing the same products.

Together the scores and details of these three areas give the customer a first-of-its-kind 360-degree view of exactly what the customer experiences are at the Agentic Commerce Engine level.

First Closed-Loop Learning Software System

Once the customer’s product catalog has been through the Commerce Intelligence Engine for the first time, the Monitor three criteria scoring is evaluated and acted on.

If the customer’s product is not visible, if there are data errors or if it does not ‘own the product card’, the Monitor capability alerts the Evaluate/Enrich agents and the customer with details of the problem(s) detected at the Agentic Shopping Engines. The Evaluate/Enrich agents then work with the customer’s input to recommend solutions and then distributes a repaired product catalog to the appropriate engine with fixes for the issues detected by Monitor. Finally, the Monitor capability evaluates that the fix has resolved the problem and if it hasn’t, the cycle repeats until all products are completely optimized. As the Agentic shopping engines change and various product catalog strategies are implemented by ReFiBuy’s agents, the system learns and adapts without code changes.

Complete Flexibility with Existing Systems and Workflows

Founded by ecommerce veterans, ReFiBuy knows that today’s digital leaders at brands, retailers and agencies have invested hundreds of millions in ecommerce platforms PIMs, ERPs and a variety of other systems. Also, modern digital commerce teams operate using complex well-oiled workflows. Because of these existing systems and workflows, ReFiBuy’s Commerce Intelligence Engine is designed to be completely flexible and integrate seamlessly with the customer’s existing systems and workflows.

For example, for our ‘ingest’ and ‘sync’ capabilities instead of bespoke system-to-system integrations, ReFiBuy has built an Agentic integration capability that automatically creates integrations to existing systems, maps the correct fields, tests, deploys and monitors the integration. Or if the customer wants to get started quickly, the system can jump-start using web data extraction.

About ReFiBuy

Founded by Scot Wingo (Founder of ChannelAdvisor/Rithum, co-host of The Jason & Scot Show), Cameron Bowe (ChannelAdvisor), James Frawley (ChannelAdvisor, MikMak), and Derek Conlin (ChannelAdvisor, Walmart), ReFiBuy is an AI-native company focused on revolutionizing digital commerce with Agentic AI. By helping retailers, brands and agencies navigate Agentic Commerce and optimize how consumers Research, Find, and Buy their products.

More information can be found at: www.refibuy.ai

Media resources are available at: https://www.refibuy.ai/media-resources

Media contact: Rebecca Ross – rebecca@refibuy.ai

Social Links:

• LinkedIn: https://www.linkedin.com/company/refibuy

SOURCE: ReFiBuy

View the original press release on ACCESS Newswire

SOUTHLAKE, TX AND AUSTIN, TX / ACCESS Newswire / September 16, 2025 / Allied OMS, the nation’s leading doctor-owned and doctor-led management services organization (MSO) for oral and maxillofacial surgeons, today announced its entry into the Greater Austin market through a partnership with Heart of Texas Oral Surgery.

Led by Dr. Jeff Alford, Heart of Texas Oral Surgery provides the full scope of oral and maxillofacial surgery services, including wisdom tooth removal, dental extractions, dental implants, corrective jaw surgery, treatment for facial pain and injuries, and care for TMJ disorders. With locations in Lakeway and Bastrop, the practice is recognized for surgical excellence, patient-centered care, and deep community roots.

“I was looking for a way to reduce the administrative burden while continuing to grow,” said Dr. Alford. “I also wanted to be part of a network of doctors I could collaborate with and help mentor. Through Allied, I’ve joined a group of peers and taken on a role in our doctor-led recruiting committee – helping shape the next generation of surgeons and raise the bar for both patient care and practice operations.”

The expansion into Austin is part of Allied’s broader Texas strategy to establish a presence in every major metropolitan area, which already includes Dallas, Fort Worth, San Antonio, and Houston.

“As Austin’s population grew rapidly, we recognized the need for additional high-quality surgical access across the region,” said Dan Hosler, CEO of Allied OMS. “Rather than building from scratch, we partnered with a respected practice that is already deeply embedded in its community and aligned with our vision for growth. I was also impressed with Dr. Alford’s growth mindset and his desire to be actively involved at the corporate level. Doctor leadership up and down through our business is a hallmark of what makes us different.”

About Allied OMS
Allied OMS is a doctor-owned, doctor-led, and doctor-governed MSO that partners with oral and maxillofacial surgery practices across the U.S. Combining the autonomy of private practice with the scale and sophistication of institutional support, Allied OMS empowers surgeons to lead the future of their specialty. The company currently supports surgeons in 50+ locations and maintains doctor leadership across all major committees and its Board of Directors. Learn more at www.alliedoms.com.

About Heart of Texas Oral Surgery
Heart of Texas Oral Surgery provides full-scope oral and maxillofacial surgical care to patients across the Greater Austin area through its offices in Lakeway and Bastrop. Led by Dr. Jeff Alford, a board-certified oral and maxillofacial surgeon with a background in both surgical and restorative dentistry, the practice is known for its commitment to clinical excellence, patient comfort, and personalized care. With expertise in wisdom teeth removal, dental implants, jaw surgery, TMJ treatment, and more, Heart of Texas Oral Surgery combines advanced technology with a compassionate approach to deliver outstanding outcomes. Learn more at www.heartoftexasoralsurgery.com.

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Media Contact

Sara Tumen Weinberg
Chief Marketing Officer
Allied OMS
sweinberg@alliedoms.com

SOURCE: Allied OMS

View the original press release on ACCESS Newswire

SIOUX FALLS SD / ACCESS Newswire / September 16, 2025 / Avel eCare is proud to join healthcare organizations nationwide in celebrating Telehealth Awareness Week, September 14-20, 2025. This year, Avel is honoring the week with a unique theme: Powered by People.

“For more than 30 years, our success has been driven by the people behind the care,” said Doug Duskin, CEO of Avel eCare. “Behind every call, every computer screen, and every virtual consult stands a team of dedicated individuals. From clinicians on the front lines to the teams in operations, technology, innovation, sales, and account management, each plays a vital role in working together to improve care and outcomes. They are the real power behind telehealth.”

From critical access hospitals to EMS crews in the field, Avel’s services showcase how telemedicine is fueled by teamwork. Clinicians provide immediate expertise during emergencies, while behind-the-scenes innovators ensure seamless technology, connectivity, and integration. Non-clinical staff-from product innovation to customer support-play an equally vital role, ensuring hospitals, schools, nursing homes, and communities receive reliable, high-quality care.

Throughout Telehealth Awareness Week, Avel will highlight different service lines and teams on its social media channels, showcasing the many ways people across the organization come together to support care delivery throughout the country

“We are Telehealth. We are Avel eCare. And we are Powered by our People.”

Telehealth Awareness Week is a national movement to spotlight the value of telehealth in expanding access, addressing disparities, and supporting healthcare teams. For Avel eCare, it is also a chance to recognize the thousands of team members and partners who make virtual care possible every day.

To learn more, visit www.avelecare.com.

Contact: Jessica Gaikowski, Avel eCare | media@avelecare.com

SOURCE: Avel eCare

View the original press release on ACCESS Newswire